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The Centre
Every liver speciality, in one place
The patient is at the heart of multidisciplinary care for diseases of the liver, bile ducts and pancreas.
▶ The Centre's 30th-anniversary film
A reference surgical centre
The Hepato-Biliary Centre performs more than 1,500 surgical procedures a year: surgery of the liver, bile ducts and pancreas, digestive oncology, and liver and pancreas transplantation.
The Centre has a dedicated operating suite, equipped with 3 minimally invasive theatres — including a Da Vinci Xi robotic theatre — and a hybrid theatre fitted with a Cone Beam CT (CBCT), bringing together advanced surgery and real-time medical imaging.
An intensive care unit specialised in liver and pancreatic diseases supports the most demanding operations, which may require extracorporeal circulation (ECC) pumps.
- Robotic surgery of the liver and pancreas
- Specialised intensive care
Our mission
To develop comprehensive care for patients with diseases of the liver and bile ducts, uniting care, research and teaching. The Centre performs the largest number of liver and pancreas transplants in France.
A landmark history
Founded in 1993 around the Paul-Brousse school of liver surgery, the Centre helped make liver transplantation a standard treatment. It bears the name of Prof. Henri Bismuth, a pioneer of liver surgery and transplantation.
Thirty years of excellence
Our history: a pioneering centre
Since its creation, the Hepato-Biliary Centre has introduced innovations that have advanced liver surgery and transplantation worldwide.
▶ The Hepato-Biliary Centre in video
Patients with a disease of the liver, bile ducts or pancreas are cared for by a multidisciplinary team — physicians, surgeons, anaesthetists-intensivists and many caregivers entirely dedicated to these diseases. All diagnostic and therapeutic resources are brought together within the department.
Built thirty years ago, the Centre has five floors. On the ground floor, consultations and endoscopy; on the first floor, five operating rooms — including one dedicated to minimally invasive surgery — and an intensive care unit specialised in liver diseases; the third floor is devoted to surgery, the fourth to the medical hepatology ward.
The main innovations introduced by the Centre
First liver transplant at Paul-Brousse Hospital (AP-HP).
World first: transplant of a child with a reduced adult liver.
World first: first emergency transplant programme for fulminant hepatitis.
One of the very first split-liver transplants in two adults from a single liver graft.
Demonstration of the feasibility of "ABO-incompatible" transplants.
Protocol to prevent recurrence of hepatitis B virus on the graft using immunoglobulin.
- First liver transplant in France for hereditary amyloid neuropathy
- First "domino" transplant in France
- Development of an auxiliary transplant programme
First international experience of resection after chemotherapy of initially unresectable colorectal liver metastases.
- First combined liver–small bowel transplant in an adult in France
- Use of the first extracorporeal bioartificial livers
- World first: transplant of three patients from a single graft, combining split liver and "domino" transplantation
- Opening of a liver transplant programme for HIV-infected patients (supported by ANRS)
- First description of two-stage hepatectomy for the resection of liver metastases
- First adult-to-adult living-donor transplant programme in France
First TIPS (transjugular intrahepatic portosystemic shunt) for severe portal hypertension, offered as an emergency treatment for gastrointestinal bleeding.
Transplant of four patients from a single graft from a deceased donor.
Early transplant programme for patients with severe acute alcoholic hepatitis.
First use of new direct-acting antivirals to treat hepatitis C in transplant patients.
- Minimally invasive hepatectomy programme for living family donors
- Rapid diagnosis device for liver tumours
First translational medicine unit in hepatology (phase I/II clinical studies).
Opening of a pancreas transplant programme.
- Rapid diagnosis device for viral hepatitis
- "Transmet" protocol for colorectal metastases
First use in France of a perfusion machine on livers from brain-dead donors.
Creation of the "Augmented Operating Room" (BOPA) innovation chair.
Introduction of ERAS: an enhanced-recovery protocol after surgery and transplantation.
- First consultation by a transplant coordination nurse
- First liver–heart transplant for cardiac cirrhosis and congenital heart disease