Our group focuses on the graft long-term follow-up including a rigorous clinical evaluation and the realization of liver biopsies performed either for clinical reasons or as part of the systematic post-transplantation protocol (at 1, 2, 5 10, 15 and 20 years after transplantation).
We have shown that some histological lesions (such as architectural and vascular lesion, atypical form of rejection, …) could insidiously develop while the liver tests were normal ( Sebagh M et al., J Hepatol 2012). Their impact on the graft outcome is currently under study.
Similarly, long term outcome of patients is a topic research in order to to improve the quality of life and survival of patients above 20 years after transplantation, and to prevent metabolic complications, recurrence of the original disease, cardiovascular complications, cancers...
Publications
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Sultanik P, Coilly A, Sebagh M, Antonini TM, Teicher E, Roche B, Samuel D, Duclos-Vallée JC. Lengthy follow-up after liver transplantation for nodular regenerative hyperplasia in human immunodeficiency virus-infected patients: does the disease recur? Transplantation. 2013 Dec 15;96(11):e79-81. PubMed
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Castillo-Rama M, Sebagh M, Sasatomi E, Randhawa P, Isse K, Salgarkar AD, Ruppert K, Humar A, Demetris AJ. "Plasma cell hepatitis" in liver allografts: identification and characterization of an IgG4-rich cohort. Am J Transplant. 2013 Nov;13(11):2966-77. PubMed
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Banff Working Group on Liver Allograft Pathology. Importance of liver biopsy findings in immunosuppression management: biopsy monitoring and working criteria
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for patients with operational tolerance. Liver Transpl. 2012 Oct;18(10):1154-70. PubMed
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Sebagh M, Samuel D, Antonini TM, Coilly A, Degli Esposti D, Roche B, Karam V, Dos Santos A, Duclos-Vallée JC, Roque-Afonso AM, Ballot E, Guettier C, Blandin F, Saliba F, Azoulay D. Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients. J Hepatol. 2012 Apr;56(4):840-7. PubMed